Mark Cuban has been unapologetically outspoken about some of America’s most entrenched industries, from health care to traditional software, advocating for transparency, efficiency, and innovation. Through his Cost Plus model, he is reshaping health care pricing. He has also declared that traditional software is “dead,” paving the way for a new era of AI and automation that will redefine how businesses operate. In this conversation, Cuban connects these seismic shifts and shares candid insights on disrupting systems, spotting emerging opportunities, and building boldly for the future.